Release of endogenous dopamine from rat isolated striatum: effect of clorgyline and (−)−deprenyl
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چکیده
منابع مشابه
Release of newly synthesized dopamine from dopamine-containing terminals in the striatum of the rat.
The extraneuronal spontaneous efflux of (3)H-dopamine synthesized endogenously in dopamine terminals has been demonstrated in vitro, by collecting the (3)H amine in superfusates of isolated striatum of the rat previously incubated with (3)H-tyrosine. The (3)H-dopamine newly synthesized appears to be preferentially released. Furthermore, amphetamine and a monoamine oxidase inhibitor (Carton) mar...
متن کاملEffects of diisopropylfluorophosphate (DFP) and other cholinergic agents on release of endogenous dopamine from rat brain striatum in vitro.
23. M. M. Bradford, Analyt. Biochem. 72,248 (1976). 24. R. J. Lee, D. B. Evans, S. M. Baky and R. J. Laffan. E. M. Brown, S. A. Fedak, C. J. Woodard, G. D. Eur. J. Pharmac. 33, 371 (1975). Aurbach and D. Rodboard, J. bioi. Chem. 251, 1239 25. E. Miyamoto, J. F. Kuo and P. Greengard, .I. biol. (1976). Gem. 244, 6395 (1969). R. S. Salter, M. M. Krinks, C. B. Klee and E. J. Neer, 26. C. S. Rabe, J...
متن کاملA thyrotropin releasing hormone analog, DN-1417, increases endogenous dopamine release from slices of rat striatum and nucleus accumbens.
Besides its hormonal effects, thyrotro pin releasing hormone (TRH) induces se veral behavioral changes in rats. Marked increases in locomotor activity occur after administration of TRH and its analogs. This effect was hypothesized to be due to a stimulation of mesolimbic dopaminergic neurons (Miyamoto and Nagawa, 1977; Heal and Green, 1979). TRH has no effect on the reuptake of monoamines (Tuom...
متن کاملEffects of NADH on dopamine release in rat striatum.
Nicotinamide adenine dinucleotide (NADH) may be utilized for the synthesis and regeneration of tetrahydrobiopterin (BH(4)), which in turn is an essential cofactor for tyrosine hydroxylase, the rate-limiting enzyme in the synthesis of dopamine (DA). NADH has been reported to relieve some of the symptoms of Parkinson's disease, presumably by altering dopaminergic function. The present study exami...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1984
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.1984.tb16228.x